TLDR; tell me if this is a waste of time before I spend forever tinkering on something that will always be janky

I want to run multiple OSs on one machine including Linux, Windows, and maybe OSX from a host with multiple GPUs + igpu. I know there are multiple solutions but I’m looking for advice, opinions and experience. I know I can google how-to but is this worh pursuing?

I currently dual boot Bazzite and Ubuntu, for gaming and develoent respectively. I love Bazzite ease of updates and Ubuntu is where it’s at for testing and building frontier AI/ML tools.

What if I kept my computer running a thin hypervisor 24/7 and switched VMs based on my working context? I could pass through hardware as needed.

Proxmox? XCP-NG? Debian + QEMU? Anyone living with these as their computing machines (not homelabs/server hosts)?

This is inspired by Chris Tidus’s (YouTube) setup on arch but 1) i don’t know arch 2) I have a fairly beefy i7 265k 192gb build, but he’s on an enterprise xenon ddr5 build so in a differenrent power class 3) I have a heterogenous mix of graphics cards I’m hoping to pass though depending on workload

Use cases:

• Bazzite + 1 gpu for gaming
• Ubuntu + 1 or more GPUs for work
• Windows + 0 or more GPU Music Production paid vstis and kernel-level anti cheat games (GTAV, etc)
• OSX? Lightroom? GPU?

Edit: Thank you all for your thoughts and contributions

Edit: what I’ve learned

• this is viable but might be a pain
• a Windows VM for getting around anti-cheat in vames defeats the purpose. I’d need a dual boot for that use case
• hyperV is a no. Qubes Qemu libvirt, yes
• may want to just put everything on sparate disks and boot / VM into them as needed

Edit: distrobox/docker works great but doesn’t fit all my needs because I can’t install kernel-level modules in them (AFAIK)